Journal: Cancers

Article Title: Simultaneous Identification of EGFR, KRAS, ERBB2, and TP53 Mutations in Patients with Non-Small Cell Lung Cancer by Machine Learning-Derived Three-Dimensional Radiomics

doi: 10.3390/cancers13081814

Figure Lengend Snippet: Pipeline step diagram of machine learning-derived radiomics.

Article Snippet: One radiologist with 18 years of experience in diagnostic imaging, who was blinded to the results of the NGS test, performed semi-automated three-dimensional (3D) tumor segmentation, using a radiomics analysis software package (Radiomics 1.0.9a, Siemens Healthineers) on a research platform (SyngoVia VB10b, Research Frontier, Siemens Healthineers).

Techniques: Derivative Assay

Journal: Cancers

Article Title: Simultaneous Identification of EGFR, KRAS, ERBB2, and TP53 Mutations in Patients with Non-Small Cell Lung Cancer by Machine Learning-Derived Three-Dimensional Radiomics

doi: 10.3390/cancers13081814

Figure Lengend Snippet: Receiver operating characteristic curves for discriminating mutations by the radiomics model and combined model (radiomic features and clinical factors).

Article Snippet: One radiologist with 18 years of experience in diagnostic imaging, who was blinded to the results of the NGS test, performed semi-automated three-dimensional (3D) tumor segmentation, using a radiomics analysis software package (Radiomics 1.0.9a, Siemens Healthineers) on a research platform (SyngoVia VB10b, Research Frontier, Siemens Healthineers).

Techniques:

Journal: Cancers

Article Title: Simultaneous Identification of EGFR, KRAS, ERBB2, and TP53 Mutations in Patients with Non-Small Cell Lung Cancer by Machine Learning-Derived Three-Dimensional Radiomics

doi: 10.3390/cancers13081814

Figure Lengend Snippet: Representative CT images with tumor segmentation by a radiomics analysis platform. ( A ) A 30-year-old female non-smoker, with EGFR mutation in lung adenocarcinoma. A lobulated solid mass is observed in the lower lobe of the right lung. The maximum diameter is 23 mm. ( B ) A 64-year-old male smoker, with KRAS mutation in lung adenocarcinoma. A solid mass with rough margin is observed in the upper lobe of the left lung. The maximum diameter is 10 mm. ( C ) A 74 year-old female non-smoker, with ERBB2 mutation in lung adenocarcinoma. A lobulated solid mass is observed in the middle lobe of the right lung. The maximum diameter is 18 mm. ( D ) A 66-year-old male smoker, with TP53 mutation in lung adenocarcinoma. A lobulated solid mass with rough margin is observed in the lower lobe of the right lung. The maximum diameter is 12 mm.

Article Snippet: One radiologist with 18 years of experience in diagnostic imaging, who was blinded to the results of the NGS test, performed semi-automated three-dimensional (3D) tumor segmentation, using a radiomics analysis software package (Radiomics 1.0.9a, Siemens Healthineers) on a research platform (SyngoVia VB10b, Research Frontier, Siemens Healthineers).

Techniques: Mutagenesis